Misa has long blonde hair, most commonly worn in pigtails, although she occasionally wears it loose as well. In the manga, her eyes are predominantly light brown. However, they have been shown as green. In the anime, they alternate between light brown and blue.
Misa often dresses in Lolita styled clothing, though noticeably less so after the time skip. In artwork drawn by Ohba, she is often seen wearing a wide range of Lolita-styled clothing.